The vital substance is significantly involved in the detoxification of xenobiotics (foreign, mostly chemical substances such as pesticides, preservatives), heavy metals and harmful mould toxins
In a rat model of adjuvant-induced arthritis, the combination of metformin (200 mg/kg/day) and omega-3 (300 mg/kg/day) showed efficacy comparable to methotrexate (2 mg/kg/week) in ameliorating disease activity, with significant reductions in arthritic scores, paw swelling, and serum TNF- and IL-1 after 4 weeks (252)
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Curr Opin Psychiatry 2014
